In brief, autism is a group of disorders with genetic and environmental causes. ASD children have evidence of abnormalities in the brain during the first 2 years of life. This may be attributed to inflammation, and the lymph flow from the meningeal lymphatic system in the brain may be a factor.

ASD children appear to have increased cerebrospinal fluid (CSF) in the folds and spaces around the brain (extra-axial spaces). Increased extra-axial spaces correlate with an increase in severity of autism symptoms, and the reason for the increase in the fluid has only recently been discovered.

The hypothesis put forward by Dr’s Bradstreet & Ruggerio “as we can now see that there is a lymphatic system in the brain, and that ASD shows an increase in extra-axial fluid, can the increase in extra-axial fluid be attributed to infections and inflammation, while a reduction in lymph drainage may also contribute to the increase in extra-axial fluid?”

ASD pathogenesis shows chronic infection, with immune dysregulation and brain inflammation that can be attributed to a group of polyomaviruses. This inflammation creates a blockage in the lymphatic drainage system, toxins cannot be removed from the brain & neither can good microbes provide nourishment to the brain. Additionally this swelling would appear to put pressure on parts of the brain responsible for cognition & speech.

Transcranial sonography may help to identify those children at risk of ASD and may establish the effectiveness of the brain lymphatic system drainage.

The conclusion is that a poor lymphatic drainage may increase fluid pressure around the brain and may be responsible for some of the symptoms of autism.

How is this relevant to GcMAF?

GcMAF, aka Vitamin D Transport Protein, is a multi functional protein that, alongside many other important functions, feeds our immune cells. Without it our immune cells remain dormant and our immunity is compromised. This has been proven to be the case in over 85% of those autistic children studied in Dr Bradstreet’s reports.

So we feed our immune cells and they will reach full maturity within 72hrs, during this time it is common that the child displays symptoms such as lethargy, headaches or low-grade fevers.

Fever is a very effective and wise reaction that has developed in all mammals and humans. Because viruses, bacteria and pathogens multiply rapidly their membranes are thinner than those of naturally occurring cells and the fever weakens the membrane which makes them more vulnerable to an immune attack, or permanently disabling them. The rise in temperature also stimulates the white blood cells in our immune system resulting in further immune activation. Dr Bradstreet covers fever in his paper:

Despite concerns about autoimmunity in autism, none of the patients observed in this study experienced significant side-effects, and none were required to suspend or drop out of treatment.

During the first few weeks of treatment, 3 of 40 patients (7.5%) experienced low to moderate rise in body temperature, typically occurring 24 to 48 hours after the GcMAF injection and lasting less than 24 hours. Parents were instructed to use ibuprofen only if the temperature exceeded 102°F (approximately 39°C), and two were treated during the first few weeks.

By the second month, no patients experienced significant febrile events. Interestingly, during the first 3 weeks, 6 of 40 patients (15%) were observed to have rashes compatible with viral exanthemas (generally on the trunk and in fine papules more commonly than maculae). Petechiae were not observed. These rashes could represent the manifestation of latent or persistent viral infections interacting with activated macrophages.

Dr’s Bradstreet & Rugerrieo, working from a clinic in Switzerland, offered a treatment protocol for children with autism that lasted 5 days. On the 1st day the brain was scanned and any inflation was mapped out. Then, after 5 days of nebulizing a variant of GcMAF called Goleic, the brain was measured again. The results were very encouraging, reduced inflammation and improved cognition.

Our immune cells have access to every part of our body and, the newly stimulated immune system appears to direct all of its energies on first eliminating viruses from the brain. So, after starting GcMAF, low-grade fevers, headaches and lethargy are often observed within the first week, consistent with viral infections and usually last a few days. What is commonly reported over the following weeks is a desire from the child to speak, and often they do. Sometimes these are the first words ever spoken. Other commonly reported gains for this period are improved socialization, cognition, health, sleep & more affection.

The beauty of using one’s own immune system to defeat any virus is that it will create an army of immune memory cells to counter act any return of the virus. After this the body creates another immune army consisting of macrophages and helper t-cells. Together they work as a finely orchestrated team of cellular-engineers, clearing metals and other toxins, while repairing the brain.


  1. Initial Observations of elevated Nagalase activity associated with Autism and observed reductions from GcMAF
  2. Structural and functional features of central nervous system lymphatic vessels
  3. Association of autism with polyomavirus infection in postmortem brains
  4. A new methodology of viewing extra-axial fluid and cortical abnormalities in children with autism via transcranial ultrasonography
  5. Brain anatomy of autism spectrum disorders II. Focus on amygdala.
  6. Regional cerebellar volumes predict functional outcome in children with cerebellar malformations.


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